SUGARY DIABETES IN THE MODEL RATS LARGE SALIVA IN THE GLANDS DEGENERATIVE-DYSTROPHIC OF PROCESSES MORPHOLOGICAL ANALYSIS

Abstract

In this study, the degenerative-dystrophic processes that develop in the major salivary glands of rats under the conditions of an experimental model of diabetes mellitus were morphologically evaluated. The aim of the work was to comprehensively characterize the structural reconstructions that occur in the parenchyma and stromal components against the background of metabolic shifts characteristic of diabetes. A streptozotocin-induced diabetes model was used as a methodology; samples taken from the submandibular, preauricular and sublingual salivary glands were analyzed by histological staining and morphometry. The scientific novelty is to substantiate the simultaneous occurrence of microcirculatory disorders, atrophy of the secretory departments, reactive reconstruction of the ductal epithelium and stromal fibrosis in the major salivary glands in diabetes as an interrelated cascade. The results indicate that the identification of morphological markers corresponding to ischemia and oxidative stress in the pathogenesis of diabetic sialadenopathy is of diagnostic and preventive approaches for important that it is shows.